Lighting up proteins with Immuno-SABER

To better understand how tissues and organs develop, fail to function, and regenerate over time, researchers would like to visualize their constituent cells' repertoires of molecules within 3-D space. Ambitious efforts like ...

Cell: Protein folding via charge zippers

Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, ...

Directed evolution builds nanoparticles

The 2018 Nobel Prize in Chemistry went to three scientists who developed the method that forever changed protein engineering: directed evolution. Mimicking natural evolution, directed evolution guides the synthesis of proteins ...

Dynamic risk management in cell populations

Much like investors in the stock market, cell populations prepare for changes in the environment by spreading the risk. The tool box they use contains a repertoire of sensory receptors on the surface of individual cells. ...

How cells protect themselves from mitochondrial defects

Cells need powerhouses known as mitochondria to utilize the energy stored in our food. Most of the proteins required for this powerhouse function are encoded in the nucleus and transported into the mitochondria after they ...

How signaling proteins get to the mitochondrial surface

Mitochondria are organelles that are known for providing the energy currency that fuels chemical reactions within cells, but they are also involved in other important processes vital for cell health including the innate immune ...

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