Designer of protein factories exposed

For 10 years, Patrick Cramer and his colleagues at Ludwig-Maximilians-Universitaet (LMU) in Munich have probed the structure of RNA polymerase I, a crucial cog in the machinery of all cells. Now they unveil the full three-dimensional ...

The ribosome: A new target for antiprion medicines

New research results from Uppsala University, Sweden, show that the key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery ...

Wound healing: 'See-saw' switch sends cells on the march

Many genes are transcribed into messenger RNA (mRNA) molecules that provide instructions for protein synthesis. Other genes encode regulatory RNAs known as 'microRNAs', which can block protein translation by binding to specific ...

Viable and fertile fruit flies in the absence of histone H3.3

Histones—proteins that package DNA—affect cell function differently than previously assumed: the cell doesn't need the histone H3.3 to read genes. Molecular biologists from the University of Zurich demonstrate that fruit ...

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