Study uncovers structural features regulating mRNA processing
RNA is the central tenet of molecular biology, the stepping-stone between DNA and proteins.
RNA is the central tenet of molecular biology, the stepping-stone between DNA and proteins.
Biotechnology
Feb 4, 2021
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572
In a recent paper in RNA Biology, researchers show that mitochondria translocate their key RNA methyltransferase enzyme, TRMT1, into host cell nuclei in response to neural activity. This subcellular relocalization of key ...
Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues. Although great improvements in cellular throughput have been made, ...
Biotechnology
May 7, 2020
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37
A research team at Children's Hospital of Philadelphia (CHOP) has developed an innovative computational tool offering researchers an efficient method for detecting the different ways RNA is pieced together (spliced) when ...
Molecular & Computational biology
Mar 25, 2019
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204
A tool that has already revolutionized disease research may soon get even better, thanks to an accidental discovery in the bacteria that cause many of the worst cases of meningitis.
Biotechnology
Feb 15, 2018
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377
UCLA researchers have solved the high-resolution structure of a massive cellular machine, the spliceosome, filling the last major gap in our understanding of the RNA splicing process that was previously unclear.
Biochemistry
Nov 17, 2017
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8
A research project that began 20 years ago with an interest in how lithium treats mood disorders has yielded insights into the progression of blood cancers such as leukemia. The research, which centers on a protein called ...
Biochemistry
Oct 31, 2017
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25
Scientists have found a single protein—Ptbp2—controls a network of over 200 genes central to how developing sperm move and communicate. The protein works by regulating how RNA is processed during each stage of sperm development.
Cell & Microbiology
Jul 10, 2017
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3
Researchers from Princeton University and the National Institute of Environmental Health Sciences have discovered how a fruit fly protein binds and regulates two different types of RNA target sequence. The study, which will ...
Cell & Microbiology
Apr 4, 2017
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222
It's well known that when the DNA in a cell is damaged, the cell responds by activating specific genes that help defend the integrity of its genome. But less well studied is the fact that the cell actually shuts down the ...
Cell & Microbiology
Feb 17, 2017
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14