Studying cells in reduced dimensions

Single-cell RNA sequencing is a powerful tool for identifying transcriptomic variations and developmental trajectories in cell types that determine the course of diseases like cancer, with the goal of eventually improving ...

SNIPRs take aim at disease-related mutations

A typo appearing in the draft of a novel is no great calamity. Nature, however, is often less forgiving of errors. A change in just one letter of the genetic code can have catastrophic consequences for human health.

Molecular biologists reveal new insights into tumor progression

University of Delaware molecular biologist Mona Batish and collaborators at Harvard Medical School and University of California, Los Angeles, have identified a new circular ribonucleic acid (RNA) that increases tumor activity ...

SABER tech gives DNA and RNA visualization a boost

Researchers have been using "Fluorescence in situ hybridization" (FISH) analysis for decades to literally fish for specific DNA and RNA sequences in intact cells and tissues within their vast seas of nucleic acid molecules. ...

Symbionts as lifesavers

When people fall ill from bacterial infection, the first priority is to treat the disease. But where do these pathogens come from, and how do they thrive in the environment before the infection occurs? An international team ...

BRB-seq: The quick and cheaper future of RNA sequencing

RNA sequencing is a technique used to analyze entire genomes by looking at the expression of their genes. Today, such genome-wide expression analyses are a standard tool for genomic studies because they rely on high-throughput ...

Single cell transcriptomics: A new sequencing approach

Researchers from University of Southern Denmark, Wellcome Sanger Institute and BGI have published a study in the journal Genome Biology comparing the library preparation and sequencing platforms for single-cell RNA-sequencing ...

The regeneration of a cell depends on where it is positioned

A simple tissue sample from a plant, like a branch or leaf, can grow into a whole new plant. This ability could have applications in the production of food, biomass and medicine, and the genes responsible for regeneration ...

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