Production of iPS cells: Discovery of the fifth element

Since 2006, research has succeeded in generating, from specialised adult cells, induced pluripotent cells (iPS cells), with huge potential applications, particularly for regenerative medicine. However, the process has still ...

OSKM stoichiometry determines iPS cell reprogramming

Researchers at Kyoto University's Center for iPS Cell Research and Application discover a simple way to increase the production of induced pluripotent stem cells. A major hurdle in reprogramming science is generating a sufficient ...

New protagonist in cell reprogramming discovered

A group of researchers from the Centre for Genomic Regulation in Barcelona have described the role of a protein that is crucial for cell reprogramming. The discovery also details the dynamics of this protein as well as its ...

Animal-free reprogramming of adult cells improves safety

Human stem cells produced through genetic reprogramming are beset by safety concerns because current techniques alter the DNA of the stem cells and use material from animals to grow them. Now, A*STAR researchers have developed ...

A protein required for integrity of induced pluripotent stem cells

Cell reprogramming converts specialised cells such as nerve cells or skin cells towards an embryonic stem cell state. This reversal in the evolutionary development of cells also requires a reversal in the biology of telomeres, ...

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