Researchers from the University of Toronto's Institute for Biomaterials and Biomedical Engineering (IBBME) and the Donnelly Centre have discovered a population of cells – dubbed to be "elite" – that play a key role in ...
Cell & Microbiology
Mar 22, 2019
0
417
Researchers at the School of Medicine have identified a new protein critical to the production of induced pluripotent stem cells, or iPS cells.
Cell & Microbiology
Jul 17, 2018
0
280
During the reprogramming of somatic cells back into stem cells, gene regulation is controlled by pioneer transcription factors. These bind to the tightly packaged DNA in order to make it accessible.
Molecular & Computational biology
Feb 26, 2024
0
14
Research from the Babraham Institute has developed a method to "time jump" human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute's ...
Cell & Microbiology
Apr 7, 2022
0
376
Researchers from the Babraham Institute's Epigenetics research program have been able to learn more about naïve stem cell reprogramming following a genome wide functional screen. Their research, published today in Science ...
Biotechnology
Mar 25, 2022
0
92
The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...
Cell & Microbiology
Dec 21, 2021
0
8
In an advance that promises to facilitate research into stem cells and regenerative medicine, a RIKEN-led team has demonstrated a non-invasive method for tracking the chemical changes that accompany the reprogramming of somatic ...
Analytical Chemistry
Feb 12, 2021
0
22
The replacement of lost neurons is a holy grail for neuroscience. A new promising approach is the conversion of glial cells into new neurons. Improving the efficiency of this conversion or reprogramming after brain injury ...
Cell & Microbiology
Nov 17, 2020
0
458
New insights into an elusive process that protects developing sperm cells from damage in growing embryos, sheds light on how genetic information passes down, uninterrupted, through generations.
Molecular & Computational biology
Jul 17, 2020
3
1541
A new use of an old mathematical method analyzes a massive single-cell RNA sequencing experiment to explore how cells move from one state to another.
Cell & Microbiology
Feb 1, 2019
1
57
