A protein complex prevents the repair of genome damage in human cells, in mice and in the nematode Caenorhabditis elegans, a team of researchers at the University of Cologne has discovered. They also successfully inhibited ...
Cell & Microbiology
Mar 23, 2023
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In human chromosomes, DNA is coated by proteins to form an exceedingly long beaded string. This "string" is folded into numerous loops, which are believed to help cells control gene expression and facilitate DNA repair, among ...
Cell & Microbiology
Apr 14, 2022
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275
If a bone breaks or a tendon snaps, you know to seek treatment immediately. But your most fragile and precious cellular commodity, chromosomal DNA, breaks with astounding frequency—some estimate as many as 10,000 times ...
Biotechnology
Dec 2, 2019
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126
Day in and day out, in our bodies, the DNA in cells is damaged for a variety of reasons, and thus intercellular DNA-repair systems are fundamental to the maintenance of life. Now scientists from the UNC School of Medicine ...
Cell & Microbiology
Feb 7, 2017
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(PhysOrg.com) -- Scientists have discovered how a network of repair proteins enables bacteria to prioritise the repair of the most heavily used regions of the DNA molecules that carry the instructions necessary for living ...
Cell & Microbiology
Dec 10, 2010
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0
Scientists have observed, for the first time, an intermediate stage in the chemical process that repairs DNA methylation damage and regulates many important biological functions that impact health conditions such as obesity, ...
Biochemistry
Nov 10, 2010
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0
Scientists have shown in multiple contexts that DNA damage over our lifetimes is a key mechanism behind the development of cancer and other age-related diseases. Not everyone gets these diseases, because the body has multiple ...
Biochemistry
Apr 11, 2010
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Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the highly regulated enzymatic ...
Cell & Microbiology
Jul 10, 2023
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92
Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair damaged DNA may induce ...
Molecular & Computational biology
Jun 12, 2023
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31
A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.
Cell & Microbiology
May 16, 2023
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