The lab of Kathy Gould, Louise B. McGavock Professor and professor of cell and developmental biology, used a multi-disciplinary approach that included structural biology, biochemistry, and molecular biology to investigate ...
Cell & Microbiology
May 9, 2022
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21
Structural biologists at the Friedrich Miescher Institute for Biomedical Research have resolved the 3D structure of a protein machine that plays an important part in the maintenance of genomic stability. They have revealed ...
Cell & Microbiology
Feb 21, 2014
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When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis.
Biochemistry
Apr 10, 2009
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(Phys.org) —NIST researchers recently reported a novel approach for identifying and quantifying an important DNA repair enzyme in mammals including humans. This enzyme, apurinic/apyrimidinic endonuclease 1 (APE1), plays ...
Analytical Chemistry
Jan 8, 2014
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By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks—which drive every cellular process from protein ...
Cell & Microbiology
Oct 28, 2019
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The severe and debilitating genetic disease Xeroderma pigmentosum impedes cells to repair UV-induced DNA damage. Scientists from CeMM found a drug approved for diabetes treatment to alleviate the impact of the gene defect ...
Cell & Microbiology
Nov 20, 2017
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3
When investigating cancer cells, researchers discovered numerous peculiarities: Particular RNA molecules are present in large numbers, particular genes are overactive. Do these characteristics have a relation to cancer? Do ...
Biotechnology
Aug 24, 2011
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Like doctors making house calls, some DNA repair enzymes can relocate to the part of the cell that needs their help, a collaborative team of scientists at Emory University School of Medicine has found.
Cell & Microbiology
Mar 26, 2009
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One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair.
Biochemistry
May 4, 2009
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Important advances in the understanding of DNA topoisomerases are discussed in a new review led by John Innes Centre researchers.
Cell & Microbiology
Mar 16, 2021
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