Structure of a central component of the human immune system revealed

A central component of the human immune system, the NLRP3 inflammasome plays an important role in fighting off infections. However, its chronic activation is also implicated in a variety of common diseases, such as Alzheimer's, ...

Review: PROTACs targeting epigenetic proteins

The field of epigenetics focuses on alterations in gene function that are inherited without changes in the DNA sequence, including histone modifications, post-translational modifications of amino acids, and covalent modifications ...

A new way to see the activity inside a living cell

Living cells are bombarded with many kinds of incoming molecular signal that influence their behavior. Being able to measure those signals and how cells respond to them through downstream molecular signaling networks could ...

Research dives into the social network of proteins

Stanley Milgram's groundbreaking "Six Degrees of Separation" experiment demonstrated the surprisingly close connections among humans back in the 1960s. Now the research team led by Professor Matthias Mann at the Max Planck ...

Intercellular messengers reveal themselves

The cells in our body continuously keep each other informed. They do this by exchanging, among other things, virus-like vesicles. Pascale Zimmermann's group, from the Department of Human Genetics, has been studying these ...

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