Making sense of antisense gene silencing

Gene silencing therapies are used to interfere with, or 'silence', the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies ...

Three-in-one approach boosts the silencing power of CRISPR

Originally discovered as a bacterial mode of defense against invading viruses, the remarkable ability of CRISPR-Cas9 to modify specific locations of DNA has made it a researcher favorite among gene editing tools. The ongoing ...

How long-known genes continue to surprise researchers

The human genome was sequenced around 20 years ago. Since then, the sequence information encoding our proteins is known—at least in principle. However, this information is not continuously stored in the individual genes, ...

Crosslinker protein helps egg cells develop

A protein helps direct the flow of materials in the Drosophila ovary during the development of egg cells, according to a Northwestern Medicine study published in Current Biology.

Researchers improve efficiency and accessibility of CRISPR

One of the most powerful tools available to biologists these days is CRISPR-Cas9, a combination of specialized RNA and protein that acts like a molecular scalpel, allowing researchers to precisely slice and dice pieces of ...

Researchers reveal key information about how genes turn on and off

Human bodies have roughly 30,000 genes dictating not only how we look, but also critical biological processes. Now, a Florida State University and Australia National University research team has discovered a key aspect of ...

Using CRISPR to lower cholesterol levels in monkeys

A team of researchers from Verve Therapeutics and the Perelman School of Medicine at the University of Pennsylvania has developed a CRISPR gene-editing technique that lowered the levels of cholesterol in the blood of test ...

How plants leave behind their parents' genomic baggage

Passing down a healthy genome is a critical part of creating viable offspring. But what happens when you have harmful modifications in your genome that you don't want to pass down? Baby plants have evolved a method to wipe ...

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