Revising the meaning of 'prion'

A team of Whitehead Institute and Stanford University scientists are redefining what it means to be a prion—a type of protein that can pass heritable traits from cell to cell by its structure instead of by DNA.

Small change makes a big difference for ion channels

Using a high-resolution single-molecule study technique, University of Illinois researchers have seen the very subtle differences between two branches of an important family of neurotransmitter-gated ion channels.

Dual brake on transport protein prevents cells from exploding

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing. To counter this, bacteria can increase their internal solute concentration. Scientists from the University ...

Study analyzes role of PARP enzyme in eukaryotes

An Ohio State University molecular biologist leveraged a supercomputer to help better define the family tree of a group of enzymes that have been implicated in a wide range of human diseases and are important targets for ...

'Hotspot mapping' accelerates early-phase drug design

The amount of structural data on protein drug targets continues to grow. However, successfully mining this data to form testable hypotheses that drive drug discovery can prove challenging. Selectivity for the target protein ...

Revealing camouflaged bacteria

A research team at the Biozentrum of the University of Basel has discovered an protein family that plays a central role in the fight against the bacterial pathogen Salmonella within the cells. The so called interferon-induced ...

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