The RNA that snips and stitches RNA

RNA is a fundamental molecule that codes for protein and controls gene expression, playing a part in regulating many cell responses and vital processes. The genetic information contained in premature messenger RNA (mRNA), ...

Scientists find way to block stress-related cell death

Scientists from the Florida campus of The Scripps Research Institute have uncovered a potentially important new therapeutic target that could prevent stress-related cell death, a characteristic of neurodegenerative diseases ...

Fibroblasts invade at a snail's pace

A transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue of the Journal ...

Stabilizing chromosomes to tackle tumors

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether. An enzyme called ...

Working in concert

As cells go about the process of building new proteins, each amino acid gets delivered individually to the protein-synthesizing machinery of the ribosome by a specialized transfer RNA (tRNA) molecule. This process is generally ...

Novel chemistry for new class of antibiotic

University of Adelaide research has produced a potential new antibiotic which could help in the battle against bacterial resistance to antibiotics.

Vulnerability found in some drug-resistant bacteria

Using a complex modeling program that helps analyze the physical dynamics of large, structurally complex protein molecules, a research team has made progress towards finding a weak spot in the architecture of a group of enzymes ...

Researchers report first 3-D structure of DHHC enzymes

The first three-dimensional structure of DHHC proteins—enzymes involved in many cellular processes, including cancer—explains how they function and may offer a blueprint for designing therapeutic drugs. Researchers have ...

New nanoparticles could revolutionize therapeutic drug discovery

A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council which could lead to 30 per cent more proteins being available as potential ...

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