Proteins are the essence of life: they give structure to cells and organelles, catalyze metabolic reactions, build, break, tug, and pull—they carry out most of the actions that sustain a cell's existence.
Biotechnology
Jun 9, 2021
0
10
Polypharmacology—the ability of a drug to affect more than one protein—should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical ...
Biochemistry
Jun 2, 2021
0
6
In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic ...
Molecular & Computational biology
Jun 1, 2021
0
12
A cutting-edge digital tool that will make it cheaper, safer and faster for pharmaceutical companies to predict protein stability—a vital step in the development of new medicines—is being rolled out by scientists from ...
Biochemistry
May 27, 2021
0
8
In the search for treatments for COVID-19, many researchers are focusing their attention on a specific protein that allows the virus to infect human cells. This protein, which cells carry on their surface, is called angiotensin ...
Cell & Microbiology
May 5, 2021
0
13
Almost all bacteria rely on the same emergency valves—protein channels that pop open under pressure, releasing a deluge of cell contents. It is a last-ditch effort, a failsafe that prevents bacteria from exploding and dying ...
Molecular & Computational biology
Apr 13, 2021
0
280
Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein's interactions with SARS-CoV-2 genetic material.
Biochemistry
Apr 5, 2021
0
235
Most drugs operate via the membranes that surround the body's cells. A study by researchers at Karolinska Institutet in Sweden has now mapped the structure and mechanism of MGST2, a membrane enzyme that, amongst other things, ...
Molecular & Computational biology
Mar 19, 2021
0
16
Drugs can only work if they stick to their target proteins in the body. Assessing that stickiness is a key hurdle in the drug discovery and screening process. New research combining chemistry and machine learning could lower ...
Biotechnology
Mar 15, 2021
0
362
Protein hydrogels, three-dimensional macromolecular structures that do not dissolve in water (in spite of being hydrophilic), can hold large quantities of aqueous solutions due to the network formed from chemical or physical ...
Polymers
Mar 11, 2021
0
6
