A new study shows that it is possible to use an imaging technique called cryo-electron microscopy (cryo-EM) to view, in near-atomic detail, the architecture of a metabolic enzyme bound to a drug that blocks its activity. ...
General Physics
May 7, 2015
0
56
(Phys.org)—Protein folding is the process by which a polypeptide (a linear organic polymer chain consisting of many amino acid residues, or monomers) transforms from a random coil into the 3D conformation in which it can ...
A research team from the National Physical Laboratory (NPL), the University of Edinburgh and IBM's TJ Watson Research Center has revealed a major breakthrough in the modelling of water that could shed light on its mysterious ...
Condensed Matter
Jun 4, 2013
3
2
If asked how today's toughest medical problems are being solved, most people would probably envision highly skilled physicians and scientists working countless hours with sophisticated lab equipment, not people sitting in ...
Other
Aug 31, 2012
0
0
Proteins are the molecular machines that make all living things hum—they stop deadly infections, heal cells and capture energy from the sun. Yet because our basic understanding of how proteins work has until now remained ...
Molecular & Computational biology
Feb 7, 2020
4
55
It may seem counterintuitive to many, but metal ions play a critical role in life, carrying out some of the most important biological processes. Think of hemoglobin—a metalloprotein responsible for carrying oxygen to the ...
Biochemistry
Mar 4, 2022
0
89
The stage is set for a new era of data-driven protein molecular engineering as advances in DNA synthesis technology merge with improvements in computational design of new proteins.
Biochemistry
Jul 13, 2017
0
32
Proteins are the molecules of life. They are chemically programmed by their amino acid sequence to fold into highly organized conformations that underpin all of biological structure (e.g., hair, scales) and function (e.g., ...
General Physics
Mar 21, 2016
0
427
Synthetic proteins have been created that move in response to their environment in predictable and tunable ways. These motile molecules were designed from scratch on computers, then produced inside living cells.
Biochemistry
May 16, 2019
0
115
Structure analysis of the trypanosomal protein Cathepsin B is among the scientific breakthroughs of 2012.
Biochemistry
Dec 21, 2012
0
0
