The intracellular delivery of proteins is an important technique for unveiling the cellular functions, protein complex structure, and therapeutics. However, conventional delivery methods have several limitations.
Bio & Medicine
May 20, 2024
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13
Nature is filled with extraordinarily precise molecular shapes that fit together like a hand in glove. Proteins, for example, can assemble into a wide variety of well-defined shapes that grant them their function.
Bio & Medicine
May 10, 2024
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216
A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like ...
Biochemistry
Nov 8, 2023
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45
Researchers at Rensselaer Polytechnic Institute (RPI) have published research in Molecular Pharmaceutics predicting how proteins interact in drug development. The research is a collaboration between Amgen and the University ...
Biochemistry
Nov 21, 2022
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5
Proteins usually undergo modifications during or after their synthesis in the endoplasmic reticulum (ER) and Golgi apparatus network inside eukaryotic cells. One such modification is glycosylation, whereby sugars, such as ...
Cell & Microbiology
Jul 25, 2022
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16
Gene editing approaches promise to treat a range of diseases, but delivering editing agents to cells in animal models and humans safely and efficiently has proven challenging. Now, researchers led by a team at the Broad Institute ...
Cell & Microbiology
Jan 12, 2022
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111
Liposomes may be the unsung heroes of the COVID-19 pandemic. Without the protection of these microscopic vesicles, the delicate strands of messenger RNA (mRNA) that lie at the heart of the Pfizer and Moderna COVID-19 vaccines ...
Bio & Medicine
Nov 15, 2021
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134
More than 2 billion people worldwide are fully vaccinated against COVID-19. However, many who live in resource-limited countries haven't been able to get vaccines, partly because these areas lack temperature-controlled shipping ...
Bio & Medicine
Sep 22, 2021
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3061
Protein hydrogels, three-dimensional macromolecular structures that do not dissolve in water (in spite of being hydrophilic), can hold large quantities of aqueous solutions due to the network formed from chemical or physical ...
Polymers
Mar 11, 2021
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6
According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame. Now, researchers reporting in ACS ...
Bio & Medicine
Oct 21, 2020
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9
