Enzyme's unfrozen adventure: In crystallo protein thermodynamics

Enzymes—biocatalysts made of proteins—are hugely important molecules that catalyze the reactions and processes in living organisms. Ongoing work to understand their structures and reaction mechanisms is therefore vital ...

Researchers image atomic structure of important immune regulator

A new study by investigators from Brigham and Women's Hospital provides a biophysical and structural assessment of a critical immune regulating protein called human T-cell immunoglobulin and mucin domain containing protein-3 ...

Questioning conventional understanding of antifreeze proteins

Scientists have discovered that an ice-binding protein (fcIBP) from sea ice microalga does not fit in the conventional classification of ice-binding proteins, suggesting unknown mechanisms behind its antifreeze property. ...

How antifreeze proteins stop ice cold

How do insects survive harsh northern winters?  Unlike mammals, they don't have thick coats of fur to keep warm.  But they do have antifreeze. Antifreeze proteins (AFPs) prevent ice from forming and spreading inside their ...

Teaching a machine to spot a crystal

Protein crystals don't usually display the glitz and glam of gemstones. But no matter their looks, each and every one is precious to scientists.

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