'Rhythm' of protein folding encoded in RNA, biologists find

(Phys.org)—Multiple RNA sequences can code for the same amino acid, but differences in their respective "optimality" slow or accelerate protein translation. Stanford biologists find optimal and non-optimal codons are consistently ...

Cell: Protein folding via charge zippers

Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, ...

Molecular assembly line brings muscles into shape

Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria and at the University of Cologne, Germany have discovered the molecular basis underlying the patterned folding and assembly of muscle proteins. ...

Accelerating cellular assembly lines

The immune system generates antibodies to mark threats that need to be eliminated, and these protein complexes bind their targets with remarkable strength and selectivity. Scientists have learned how to generate cell lines ...

Raising the blockade

At crucial points in the metabolism of all organisms, a protein with the unwieldy name of Translation Elongation Factor P (EF-P, for short) takes center stage. What it actually does during protein synthesis has only now been ...

Rules devised for building ideal protein molecules from scratch

(Phys.org)—By following certain rules, scientists can prepare architectural plans for building ideal protein molecules not found in the real world. Based on these computer renditions, previously non-existent proteins can ...

New insights to the function of molecular chaperones

(Phys.org)—Heidelberg molecular biologists have gained new insights into the function of so-called molecular chaperones in protein synthesis. The team headed by Dr. Günter Kramer and Prof. Dr. Bernd Bukau of the DKFZ-ZMBH ...

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