Understanding chronic wasting disease in deer

Chronic wasting disease (CWD) is a transmissible, neurodegenerative disorder in deer that causes inability to eat, stumbling, drooling, and lack of fear of humans, and in all cases is ultimately fatal. "You can have deer ...

Prions: New possible therapeutic target discovered

Prion diseases, such as bovine spongiform encephalopathy ("mad cow disease"), are lethal neurodegenerative infectious diseases that affect humans and other mammals and for which there is currently no cure.

Can beavers catch chronic wasting disease?

Chronic wasting disease (CWD) is an infectious disease that affects the central nervous systems of animals, typically affecting cervids such as deer, elk and moose.

From good to bad with a copper switch

At the molecular level, the difference between Doctor Jekyll and Mr Hyde lies in a metal, copper. In its physiological form, the prion protein (PrPC ) is 'good' and is involved in normal body processes. It can happen, however, ...

Where does the pathological misfolding of the prion originate?

"When they are healthy, they look like tiny spheres; when they are malignant, they appear as cubes" stated Giuseppe Legname, principal investigator of the Prion Biology Laboratory at the Scuola Internazionale Superiore di ...

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