Smart drug design to prevent malaria treatment resistance
Malaria treatment resistance could be avoided by studying how resistance evolves during drug development, according to a new paper published in Cell Chemical Biology.
Malaria treatment resistance could be avoided by studying how resistance evolves during drug development, according to a new paper published in Cell Chemical Biology.
Biochemistry
May 9, 2019
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22
An international team led by Institute researchers has visualised the unique molecular 'key' used by the world's deadliest malaria parasite, Plasmodium falciparum, to enter and infect human blood cells.
Cell & Microbiology
Dec 13, 2018
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105
A study led by the Barcelona Institute for Global Health (ISGlobal) reveals a new mechanism by which the malaria parasite Plasmodium falciparum converts from its asexual to its sexual form, which can be transmitted to the ...
Plants & Animals
Nov 27, 2018
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35
The evolutionary path of the deadliest human malaria parasite, Plasmodium falciparum, has been revealed for the first time. This parasite is a member of a parasite family called the Laverania that only infect the great apes ...
Cell & Microbiology
May 21, 2018
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18
For the first time, scientists have revealed the essential genes for the most deadly human malaria parasite, Plasmodium falciparum. Researchers from the Wellcome Sanger Institute and the University of South Florida (USF) ...
Cell & Microbiology
May 3, 2018
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20
One of the biggest obstacles to eradicating malaria is a dormant form of the parasite that lurks in the livers of some patients. This dormant form is resistant to most antimalarial drugs and can reawaken months or years later, ...
Cell & Microbiology
Feb 22, 2018
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66
Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets. The team are already working with pharmaceutical companies ...
Cell & Microbiology
Feb 20, 2018
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68
Global efforts to eradicate malaria are crucially dependent on scientists' ability to outsmart the malaria parasite. And Plasmodium falciparum is notoriously clever: It is quick to develop resistance against medications and ...
Cell & Microbiology
Dec 7, 2017
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18
A promising vaccine target for the most deadly type of malaria has had its molecular structure solved by Institute researchers, helping in the quest to develop new antimalarial therapies.
Cell & Microbiology
Mar 21, 2017
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7
Two new studies from the Francis Crick Institute shed light on how the malaria parasite grows inside a host's red blood cells and breaks out when it's ready to spread to new host cells.
Cell & Microbiology
Mar 14, 2017
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180