Malaria, a mosquito-borne disease, killed more than 620,000 people worldwide in 2020. Jeopardizing the survival of Plasmodium falciparum, the malaria parasite, is one way to control the spread of this deadly disease.
Molecular & Computational biology
Mar 11, 2022
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19
Malaria is one of the most dangerous infectious diseases. The causative pathogens are microorganisms of the genus Plasmodium. A particularly dangerous form of the disease is caused by Plasmodium falciparum. Artemisinin is ...
Molecular & Computational biology
Nov 29, 2021
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62
Understanding how malaria parasites evolve after a human is bitten by an infected mosquito is very difficult. There can be billions of individual parasites in a patient's bloodstream and traditional genetic sequencing techniques ...
Evolution
Oct 13, 2021
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35
A gene called PfAP2-HS allows the malaria parasite to defend itself from adverse conditions in the host, including febrile temperatures, according to a new study led by the Barcelona Institute for Global Health (ISGlobal), ...
Cell & Microbiology
Aug 16, 2021
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108
Researchers have mapped in fine detail the genetic changes malaria parasites go through as they prepare to infect people.
Cell & Microbiology
May 27, 2021
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18
Researchers at the Francis Crick Institute have identified an enzyme vital to the survival of the malaria parasite. The work could lead to the development of a new class of antimalarial treatments which target this enzyme ...
Biotechnology
Dec 8, 2020
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38
A new computational model suggests that certain mutations that block infection by the most dangerous species of malaria have not become widespread in people because of the parasite's effects on the immune system. Bridget ...
Molecular & Computational biology
Oct 8, 2020
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14
A research team at ISGlobal, an institution supported by the "la Caixa" Foundation, has developed a system to induce massive sexual conversion of the P. falciparum malaria parasite in vitro. This technique, published in Science ...
Cell & Microbiology
Jun 10, 2020
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78
The consumption of sugar is a fundamental source of fuel in most living organisms. In the malaria parasite Plasmodium falciparum, the uptake of glucose is essential to its life cycle. Like in other cells, sugar is transported ...
Biochemistry
Jan 29, 2020
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22
An international group of researchers has proven that a molecule called TCMDC-135051 can selectively inhibit a protein that is essential to the lifecycle of Plasmodium falciparum, one of the parasites that causes malaria.
Cell & Microbiology
Oct 7, 2019
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45
