Uncovering the secret of insulin growth factor ternary complex

Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses and children, but also body maintenance and metabolism in adults. IGF regulates cell proliferation, differentiation, and survival by ...

Research team first to develop 3D structure of twinkle protein

Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases. The protein ...

Asexual reproduction leads to harmful genetic mutations

A team led by biologists at The University of Texas at Arlington has published a study supporting the theory that species that reproduce asexually have more harmful genetic mutations than those utilizing sexual reproduction.

How proteins assemble may have underappreciated role in disease

Thanks to advances in genomics in recent decades, researchers now know the genetic mutations responsible for many diseases. However, researchers often still do not know how the mutation leads to the disease—what it changes ...

How a gene mutation leads to higher intelligence

When genes mutate, this can lead to severe diseases of the human nervous system. Researchers at Leipzig University and the University of Würzburg have now used fruit flies to demonstrate how, apart from the negative effect, ...

Uncovering warped protein interactions in cancer

Scientists at Emory have revealed widespread distortions of a cell's protein interaction machinery resulting from cancer-causing mutations. They developed a process resembling ground-penetrating radar, for its ability to ...

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