Despite remarkable medical advances over the last years, cystic fibrosis remains the most prevalent lethal genetic disease. It is due to mutations in the CFTR protein which is normally required to maintain proper fluid balances ...
Biochemistry
Aug 3, 2021
0
359
A team of researchers working at the Francis Crick Institute has developed a way to find mutations in similar genome regions of cancer samples. In their paper published in the journal Nature Biotechnology, the group describes ...
One of the key mutations seen in the 'Alpha variant' of SARS-CoV-2—the deletion of two amino acids, H69/V70—enables the virus to overcome chinks in its armour as it evolves, say an international team of scientists.
Cell & Microbiology
Jun 29, 2021
1
39
Male infertility affects more than 20 million men globally and is a contributing cause to around 50% of infertility in couples. Frequently, male infertility is the result of defects in the sperm tail, the flagellum, which ...
Plants & Animals
Jun 14, 2021
0
6
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have described a potential disease-causing mechanism in hypertrophic cardiomyopathy (HCM), the most frequent hereditary disease of the heart. The ...
Bio & Medicine
Jun 10, 2021
0
7
SARS-CoV-2 has evolved to acquire mutations on the spike protein—the part of the virus that protrudes from its surface and latches onto cells to infect them—that enhance the coronavirus' ability to bind to human cells ...
Biotechnology
May 19, 2021
0
126
Using a specialized protein, all bacteria are capable of rapidly and effectively repairing damage to their DNA from UV. However, this mutation frequency decline (Mfd) protein plays another role and causes mutations. A team1 ...
Cell & Microbiology
Apr 7, 2021
0
139
A warmer global climate can cause mutations to have more severe consequences for the health of organisms through their detrimental effect on protein function. This may have major repercussions on organisms' ability to adapt ...
Ecology
Feb 2, 2021
5
415
One reason it's so difficult to produce effective vaccines against some viruses, including influenza and HIV, is that these viruses mutate very rapidly. This allows them to evade the antibodies generated by a particular vaccine, ...
Molecular & Computational biology
Jan 14, 2021
0
142
Exposure to mutagens, or mutation-causing agents, can not only bring about changes in DNA but also appear to induce errors when genes are transcribed to make proteins, which may be an important factor in age-related diseases.
Biotechnology
Dec 21, 2020
0
41
