Preventing resistance in cancer therapy

The latest developmental drugs, particularly for use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study published in Nature Chemical Biology, researchers at CeMM, the Research ...

A 'door' into the mitochondrial membrane

Mitochondria—the organelles responsible for energy production in human cells—were once free-living organisms that found their way into early eukaryotic cells over a billion years ago. Since then, they have merged seamlessly ...

Using math to predict SARS-CoV-2 protein mutations

Oak Ridge National Laboratory, the University of Tennessee at Chattanooga and Tuskegee University researchers used mathematics to predict which areas of the SARS-CoV-2 spike protein are most likely to mutate.

First mouse model with mitochondrial tRNALeu mutation developed

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial ...

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