Nanobodies could help CRISPR turn genes on and off

The genetic tool CRISPR has been likened to molecular scissors for its ability to snip out and replace genetic code within DNA. But CRISPR has a capability that could make it useful beyond genetic repairs. "CRISPR can precisely ...

Flaws emerge in modeling human genetic diseases in animals

My lab, based at the University of Southern California Keck School of Medicine, uses zebrafish to model human birth defects affecting the face. When I tell people this, they are often skeptical that fish biology has any relevance ...

Editing plant chromosomes using molecular scissors

The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants. The research teams of Professor Holger Puchta of Karlsruhe Institute of Technology (KIT) and ...

Researchers characterize molecular scissors for plastic waste

A research team from the University of Greifswald and Helmholtz-Zentrum-Berlin (HZB) has solved the molecular structure of the enzyme MHETase at BESSY II. MHETase was discovered in bacteria, and together with a second enzyme, ...

How molecular scissors cut in the right place

A research group at Uppsala University has found out how CRISPR-Cas9—also known as 'molecular scissors'—can search the genome for a specific DNA sequence. Cas9 already has many applications in biotechnology and is also ...

Molecular scissors help evolutionary investigation

Scientists at KIT (Karlsruhe Institute of Technology) detected an important mechanism in the evolution of plant genomes: Using Arabidopsis thaliana as a model organism, they studied the formation of tandem repeat DNA sequences ...

How to remove tangles in your DNA

(Phys.org) —DNA damage is a fact of life. On any given day, an organism's DNA will suffer between 10,000 and 1,000,000 breaks or other damage. These problems are repaired by enzymes in our cells that fix the breaks, remove ...

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