Making CRISPR hype more of a reality

This year, we celebrate 10 years of genome editing with CRISPR. The system is often referred to as molecular scissors, and this designation is quite accurate for its first applications. These short 10 years were marked by ...

A fine-tuned gene editor that minimizes adverse consequences

The molecular tool CRISPR-Cas9 can be used to treat inherited blood disorders, but this may cause unintended genetic alterations. A team led by MDC researchers Klaus Rajewsky and Van Trung Chu has now presented an approach ...

Nanobodies could help CRISPR turn genes on and off

The genetic tool CRISPR has been likened to molecular scissors for its ability to snip out and replace genetic code within DNA. But CRISPR has a capability that could make it useful beyond genetic repairs. "CRISPR can precisely ...

Flaws emerge in modeling human genetic diseases in animals

My lab, based at the University of Southern California Keck School of Medicine, uses zebrafish to model human birth defects affecting the face. When I tell people this, they are often skeptical that fish biology has any relevance ...

Editing plant chromosomes using molecular scissors

The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants. The research teams of Professor Holger Puchta of Karlsruhe Institute of Technology (KIT) and ...

Researchers characterize molecular scissors for plastic waste

A research team from the University of Greifswald and Helmholtz-Zentrum-Berlin (HZB) has solved the molecular structure of the enzyme MHETase at BESSY II. MHETase was discovered in bacteria, and together with a second enzyme, ...

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