Ubiquitin ligases regulate many processes in living cells. Depending on how many ubiquitin molecules they attach to the target proteins and in which way, they control the protein's fate.
Cell & Microbiology
Feb 8, 2024
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1
Within the intricate molecular landscape inside of a cell, the orchestration of proteins demands precise control to avoid disease. While some proteins must be synthesized at specific times, others require timely breakdown ...
Cell & Microbiology
Sep 21, 2023
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32
By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.
Biochemistry
Feb 15, 2023
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90
The latest developmental drugs, particularly for use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study published in Nature Chemical Biology, researchers at CeMM, the Research ...
Biochemistry
Nov 3, 2022
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32
An important function of our cells' signaling pathways is to coordinate growth with environmental cues, such as the availability of nutrients in the cell's environment. Cell growth plays an important role in normal cell function—for ...
Cell & Microbiology
Jul 14, 2022
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441
As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond to the environment and ...
Plants & Animals
Apr 28, 2022
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94
Protein degraders, which induce the protein degradation of target proteins, are expected to be the "next-generation drugs" because they can remove disease-related proteins from cells. Protein degraders, such as thalidomide ...
Molecular & Computational biology
Mar 8, 2022
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19
WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells. The discovery could help to solve the mystery cause of a rare group of ...
Cell & Microbiology
Jan 10, 2022
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96
Researchers from Osaka University have found that the attachment of a ubiquitin molecule to a protein called PCNA at the lysine 107 position causes gross chromosomal rearrangements. This lysine is located where two PCNA molecules ...
Cell & Microbiology
Jul 22, 2021
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12
UT Southwestern researchers have discovered a mechanism that cells use to degrade microRNAs (miRNAs), genetic molecules that regulate the amounts of proteins in cells.
Biotechnology
Nov 12, 2020
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234
