Stem cells balance self-renewal with differentiation into mature cells. A fundamental and intriguing question is when during the process of maturation a cell reaches a "point of no return," losing its capacity to self-renew ...
Cell & Microbiology
Dec 1, 2021
0
4
Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Peking University and Zhujiang Hospital of Southern Medical University have developed a ferritin (Fn)-based nanomedicine for ...
Bio & Medicine
Oct 25, 2021
0
63
A team of scientists from the University of Michigan Rogel Cancer Center has developed the first drug-like compounds to inhibit a key family of enzymes whose malfunction is associated with several types of cancer, including ...
Biochemistry
Aug 31, 2020
0
87
An ultra-long circulating nanomaterial has been developed by researchers through the conjugation of CHMFL-ABL-053 to an amphiphilic polymer and subsequent self-assembly into a nanoparticle (NP) with high loading.
Bio & Medicine
Aug 24, 2020
0
9
Recently, a research team led by Dr. Liu Qingsong and Dr. Liu Jing from High Magnetic Field Laboratory of the Chinese Academy of Sciences has discovered a novel FLT3-ITD mutation-selective kinase inhibitor CHMFL-FLT3-362, ...
Molecular & Computational biology
May 20, 2020
0
3
To counter drug resistance, scientists engineer new drugs to "fit" new mutations and thus kill the cancer cell or pathogen. Now, an NIBIB-funded team of Penn State engineers has a new approach for predicting which mutation ...
Cell & Microbiology
May 13, 2020
0
19
Chemistry researchers at Oregon State University have patented a method for making anti-leukemia compounds that until now have only been available via an Asian tree that produces them.
Biochemistry
Mar 20, 2019
0
109
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit ...
Biochemistry
Nov 22, 2018
0
70
A research team led by Dr. Xiang David Li from the Department of Chemistry at The University of Hong Kong (HKU), in collaboration with scientists from Tsinghua University in China, the Rockefeller University, and the University ...
Biochemistry
Nov 7, 2018
0
68
Researchers at the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, have developed a system to accelerate the discovery of chemical compounds that inhibit an enzyme ...
Biochemistry
Sep 6, 2018
0
47
