New technique developed for targeted protein degradation

A new study published in Nature Communications from researchers at Karolinska Institutet solves a long-standing problem by establishing a system that allows site-specific protein degradation within mitochondria, the cellular ...

Bat 'nightclubs' may be the key to solving the next pandemic

Bats carry some of the deadliest zoonotic diseases that can infect both humans and animals, such as Ebola and COVID-19. In a recently-published article in the journal Cell Genomics, a Texas A&M research team has revealed ...

Junk DNA in birds may hold key to safe, efficient gene therapy

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job of knocking out genes to cure hereditary disease. But it's still not possible to insert whole genes ...

Stabilizing mRNA vaccines for delivery to cells

Vaccines and therapies based on messenger RNA could be more readily delivered due to a non-toxic polymer that protects RNA and controls its release inside cells.

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Disease

A disease or medical problem is an abnormal condition of an organism that impairs bodily functions, associated with specific symptoms and signs. It may be caused by external factors, such as invading organisms, or it may be caused by internal dysfunctions, such as autoimmune diseases.

In human beings, "disease" is often used more broadly to refer to any condition that causes extreme pain, dysfunction, distress, social problems, and/or death to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories.

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