After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain ...
Cell & Microbiology
Dec 22, 2022
0
25
If you stretched the DNA found in one of your cells from end to end, it would extend approximately 2 meters or 6.5 feet. Every single cell in your body can pack away this much DNA by winding it around proteins called histones. ...
Biochemistry
Dec 19, 2022
0
157
In almost every human cell, 2 meters of DNA has to fit within a nucleus that is just 8 millionths of a meter wide. Like wool around a spool, the extreme space challenge requires DNA to wrap around structural proteins called ...
Evolution
Jun 9, 2022
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47
For some giant viruses, a DNA-packing trick may be essential for infectivity.
Cell & Microbiology
Jul 27, 2021
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268
Researchers have developed a more efficient platform for studying proteins that play a key role in regulating gene expression. The approach uses engineered yeast cells to produce enzyme and histone proteins, conduct biochemical ...
Biochemistry
Jul 1, 2021
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16
"If you can't stand the heat, get out of the kitchen," as the old saying goes. But for organisms that can't leave the proverbial kitchen when things get too hot, there's another way: researchers from Japan have discovered ...
Plants & Animals
Jun 10, 2021
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8
Northwestern Medicine scientists have developed a new method to analyze the protein composition of intact nucleosomes without losing combinatorial information present in chromatin. The technique, called Nuc-MS, could help ...
Biotechnology
May 24, 2021
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12
In the cell nucleus, histones play a crucial role packaging DNA into chromatin. Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right ...
Cell & Microbiology
Apr 14, 2021
0
18
Scientists at Tokyo Institute of Technology have deciphered how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. Using their method, they ...
Biotechnology
Dec 11, 2020
0
83
Research by Kai Jiao, M.D., Ph.D., and colleagues at the University of Alabama at Birmingham and in Germany has yielded fundamental insights into the causes of severe birth defects known as CHARGE syndrome cases. These congenital ...
Molecular & Computational biology
Dec 3, 2020
0
17
