A research team led by Professor Megumu K. Saito (Department of Clinical Application) examined the dynamic transcriptional and epigenetic landscape during definitive hematopoiesis and revealed the non-redundant roles of ZEB2 ...
Cell & Microbiology
Oct 18, 2023
0
10
A readily available, inexpensive, small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside the body, potentially improving the success of procedures such as ...
Cell & Microbiology
Sep 27, 2023
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1
In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept ...
Biotechnology
Jul 27, 2023
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69
In humanity's ongoing quest for the elixir of life, the science keeps pointing to stem cells. Research increasingly shows that maintaining stem cell fitness promotes a long healthspan, and new findings show keeping stem cells ...
Cell & Microbiology
Mar 21, 2023
0
78
Hematopoietic stem cells (HSCs) are important immature blood cells in bone marrow that can be triggered to develop into any blood cell type. HSC transplants can be used to treat conditions where bone marrow is damaged and ...
Cell & Microbiology
Feb 27, 2023
0
48
The body is constantly replenishing the blood with new red and white blood cells thanks to a small but important group of cells called hematopoietic stem cells (HSCs). Now, researchers at the Broad Institute of MIT Harvard, ...
Cell & Microbiology
Feb 17, 2023
0
20
Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. A team of researchers found ...
Cell & Microbiology
Jan 24, 2023
0
70
A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions—such as cell types or tissues.
Molecular & Computational biology
Nov 14, 2022
0
56
A well-functioning immune system is essential for protection against infections. However, with increasing age, the functioning of the immune system diminishes, which is also due to age-related damage in hematopoietic (blood) ...
Cell & Microbiology
Oct 10, 2022
0
116
The fetal liver is the major hematopoietic organ during the embryonic stage. It is generally believed that hematopoietic hierarchy in the fetal liver is established through the differentiation of fetal hematopoietic stem ...
Cell & Microbiology
Sep 21, 2022
0
58
