Rejuvenate Bio launches to help dogs live longer, healthier lives

The Wyss Institute for Biologically Inspired Engineering at Harvard University announced today that Rejuvenate Bio has secured an exclusive worldwide license from the Harvard Office of Technology Development to commercialize ...

How the Texas puma saved the Florida panther

Scientists have pieced together the first complete picture of the Florida panther genome—work that could serve to protect that endangered population and other endangered species going forward.

Scientists warn of pandemic endangering amphibians

A deadly disease affecting amphibians has descended into a global pandemic that has already wiped out 90 species, a prominent US biologist warned Thursday at the World Organisation for Animal Health Aquatic Conference in ...

Human hazards hamper vampire bat venom research

Vampire bats could hold the key to new treatments for a range of serious medical problems, but researchers have hit a snag accessing the specimens needed to advance their work.

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Heart failure

Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest (see Terminology, below).

Common causes of heart failure include myocardial infarction and other forms of ischemic heart disease, hypertension, valvular heart disease and cardiomyopathy. Heart failure can cause a large variety of symptoms such as shortness of breath (typically worse when lying flat, which is called orthopnea), coughing, ankle swelling and reduced exercise capacity. Heart failure is often undiagnosed due to a lack of a universally agreed definition and challenges in definitive diagnosis. Treatment commonly consists of lifestyle measures (such as decreased salt intake) and medications, and sometimes devices or even surgery.

Heart failure is a common, costly, disabling and deadly condition. In developing countries, around 2% of adults suffer from heart failure, but in those over the age of 65, this increases to 6—10%. Mostly due to costs of hospitalization, it is associated with a high health expenditure; costs have been estimated to amount to 2% of the total budget of the National Health Service in the United Kingdom, and more than $35 billion in the United States. Heart failure is associated with significantly reduced physical and mental health, resulting in a markedly decreased quality of life. With the exception of heart failure caused by reversible conditions, the condition usually worsens with time. Although some patients survive many years, progressive disease is associated with an overall annual mortality rate of 10%.

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