How sperm get into the zona

Before it can fertilize an egg, a sperm has to bind to and bore through an outer egg layer known as the zona pellucida. Despite decades of research, some of the biological mechanisms behind this process remain unclear. A ...

Making sense of misfolded proteins

The endoplasmic reticulum of cells provides a pivotal quality-control system that eliminates improperly folded, or misfolded, glycoproteins, such as antibodies and hormones. The UDP-glucose:glycoprotein glycotransferase (UGGT) ...

Sweet solutions for detecting disease

Based at the Institute of Chemistry in the Slovak Academy of Sciences, Ján Tkáč's research combines glycomics – the study of sugars in organisms – with biochip sensors based on nanoparticles and nanotubes. The complexity ...

Biomarkers detected for Chikungunya fever

Three specific biomarkers provide an accurate indication of the severity of Chikungunya fever (CHIKF), which is emerging as a threat in South-East Asia, the Pacific and Europe, according to research conducted in Singapore.

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