Sleeping sickness parasite uses multiple metabolic pathways

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a study published December 27 in the open-access journal PLOS Pathogens by David Horn of ...

Cellular clean-up crews linked to how body handles sugar

How our bodies handle glucose—the simple sugar that provides energy from the food we eat—appears to be intertwined with how cells keep themselves functioning normally, according to new University of Chicago research.

Bears' seasonal hibernation linked to changes in gut microbes

Each year, as bears prepare to hibernate, they gorge themselves on food to pack on fat. And yet, despite the rapid weight gain, the animals somehow avoid the health consequences so often associated with obesity in humans. ...

Hippo 'crosstalk' may be vital to tumor suppression

Think of a waterfall, and you might see why cell-signaling pathways are important to cancer research. As water cascades, it impacts everything downstream. And everything upstream affects the waterfall.

Protein essential for maintaining beta cell function identified

Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 – a beta-cell enriched transcription factor – is ...

Knocking out key protein in mice boosts insulin sensitivity

By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically boosted insulin sensitivity ...

Apple peel makes mice mighty

For Popeye, spinach was the key to extra muscle. For the mice in a new University of Iowa study, it was apples, or more precisely a waxy substance called ursolic acid that's found in apple peel.

Researchers find possible use for the vine that ate the South

Kudzu, the fast-growing vine that has gobbled up some 10 million acres in the Southeast, may prove to be a valuable dietary supplement for metabolic syndrome, a condition that affects 50 million Americans, say researchers ...

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