New York University biologists captured highly transient interactions between transcription factors—proteins that control gene expression—and target genes in the genome and showed that these typically missed interactions ...
Molecular & Computational biology
Mar 2, 2020
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40
Disruption of certain DNA structures—called topologically associating domains, or TADs—is linked with the development of disease, including some cancers. With its newly created algorithm that quickly locates and helps ...
Biotechnology
Dec 17, 2019
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215
Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants. But pluripotency is still a black ...
Cell & Microbiology
Aug 20, 2019
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16
In the field of systems biology, "big data" refers to the massive amounts of information that can be collected, stored and analyzed computationally and which can reveal previously unseen patterns or associations important ...
Biotechnology
Aug 20, 2018
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6
The sites where transcription factors bind within regulatory DNA fall into six distinct patterns that overlap with the factors' functions, Broad scientists find, helping advance a goal of regulatory genomics.
Cell & Microbiology
Jul 11, 2018
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7
Organisms that aren't closely related may evolve similar traits as they adapt to similar challenges. It's called convergent evolution, and familiar examples include the wings of birds, bats, and insects, and echolocation ...
Biotechnology
Jan 18, 2018
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31
A team of developmental biologists at the University of Massachusetts Amherst led by Dominique Alfandari, with others at MIT, report in a new paper that they have for the first time described how two transcription factors ...
Cell & Microbiology
Oct 10, 2017
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2
New research by scientists from the University of Chicago demonstrates that the enzyme ALKBH1 can remove molecular modifications from transfer RNA, causing a measurable effect on protein translation in the cell. The study, ...
Cell & Microbiology
Oct 13, 2016
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10
Scientists at the interface of biophysics, evolutionary biology and systems biology develop new framework to analyze effects of global crosstalk on gene regulation | interdisciplinary collaboration between three IST Austria ...
Cell & Microbiology
Aug 12, 2016
0
393
Scientists from A*STAR's Genome Institute of Singapore (GIS) have discovered the unique functions of a specific type of histone modification, which may prove crucial in understanding gene regulation and the development of ...
Biotechnology
Jul 11, 2016
0
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