Looking for an off switch for celiac disease

Celiac disease is an autoimmune disorder that affects by some estimates nearly 1 in 100 people. Celiac disease symptoms are triggered by gluten, a protein found in wheat and related plants, but gluten doesn't act alone to ...

Spore formation model could advance medicine

Michigan State University scientists have produced experimental and modeling results that shed light on how a particular type of enzyme functions during spore formation, potentially advancing human health and disease research.

Sticking sugar to protein

ETH researchers have succeeded in determining the 3-D structure of the enzyme that attaches sugar chains to proteins – a breakthrough that they recently published in the journal Science.

Scientists reveal double life of sunflower enzyme

Scientists have explained how a protein-cutting enzyme can join the ends of proteins together, creating protein circles; a finding with immediate applications in producing therapeutic drug treatments that is published in ...

New method to stop cells dividing could help fight cancer

Researchers at Uppsala University, Karolinska Institutet, and the University of Oxford, have used a new strategy to shut down specific enzymes to stop cells from dividing. The method, published in Cell Chemical Biology, can ...

New research could significantly accelerate drug discovery

Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side effects. One potential solution ...

Enzyme from briny deep resurrected in the lab

Mysterious microbes that thrive in hot and super-salty brine lakes at the bottom of the Red Sea could yield a treasure trove of new enzymes for industrial applications—if only scientists had access to their biological bounty.

Researchers report first 3-D structure of DHHC enzymes

The first three-dimensional structure of DHHC proteins—enzymes involved in many cellular processes, including cancer—explains how they function and may offer a blueprint for designing therapeutic drugs. Researchers have ...

Tracking protein disposal could lead to improved therapies

Northwestern Medicine investigators developed a technique to catalog how cells dispose of unnecessary proteins, a process that has implications for cancer and autism-spectrum diseases, according to findings published in Nature ...

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