Harnessing the moonseed plant's chemical know-how

In overgrown areas from Canada to China, a lush, woody vine with crescent-shaped seeds holds the secret to making a cancer-fighting chemical. Now, Whitehead Institute researchers in Member Jing-Ke Weng's lab have discovered ...

Mathematical model reveals behavior of cellular enzymes

Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton University have devised a new ...

External structure can affect the function of enzymes

A research team from Ruhr-Universität Bochum (RUB) and from South Africa has analysed two enzymes with identical substrate binding pockets that nevertheless convert different substrates. In the process, it emerged that changes ...

Anti-aging molecule NAD+ gets a boost from blocking an enzyme

Nicotinamide adenine dinucleotide (NAD+) is a major player in nutrition today. Studies have shown that NAD+ concentrations decrease during aging and that recovering the body's levels of NAD+ can prolong both health span and ...

Mapping biological functions of NUDIX enzymes

In a large multidisciplinary project, researchers at Karolinska Institutet have explored different properties of an enzyme family called NUDIX hydrolases. The study, published in Nature Communications, reveals novel insights ...

Understanding key enzyme's role in embryonic development

The catalytic activity of an enzyme called Set1A—a protein that is essential to the viability of embryonic stem cells (ESCs)—is not required for ESC self-renewal, according to a Northwestern Medicine study published in ...

Engineering the P450 enzyme to perform new reactions

Enzymes, the micro machines in our cells, can evolve to perform new tasks when confronted with novel situations. But what if you want an enzyme to do an entirely different job—one that it would never have to do in a cell? ...

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