Achilles' heel of pathogenic bacteria discovered

Multidrug-resistant bacteria remain a major concern for hospitals and nursing homes worldwide. Propagation of bacterial resistance is alarming and makes the search for new antimicrobials increasingly urgent. Scientists at ...

NUS researchers identify a novel double-stranded DNA structure

By way of mechanical stretching, National University of Singapore researchers identify a novel double-stranded DNA structure, thus successfully resolving a 16-year-old scientific debate over the existence of a double-stranded ...

Transcriptional elongation control takes on new dimensions

Life is complicated enough, so you can forgive the pioneers of DNA biology for glossing over transcriptional elongation control by RNA polymerase II, the quick and seemingly bulletproof penultimate step in the process that ...

Ready, go!

Just like orchestra musicians waiting for their cue, RNA polymerase II molecules are poised at the start site of many developmentally controlled genes, waiting for the "Go!"- signal to read their part of the genomic symphony. ...

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