Chemistry trick renews hope against killer diseases
As infections such as tuberculosis have become immune to an ever widening range of antibiotics doctors have looked on helplessly.
As infections such as tuberculosis have become immune to an ever widening range of antibiotics doctors have looked on helplessly.
Biochemistry
Dec 28, 2011
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To stay ahead in the race against drug-resistant infections, scientists constantly search for and exploit vulnerabilities in deadly bacteria. Now, researchers from Brown and the Massachusetts Institute of Technology have ...
Biochemistry
Sep 18, 2013
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Researchers at Albert Einstein College of Medicine of Yeshiva University have found two novel ways of killing the bacteria that cause tuberculosis (TB), a disease responsible for an estimated two million deaths each year. ...
Biochemistry
Mar 21, 2010
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A novel way of synthesising a promising new antibiotic has been identified by scientists at the University of Bristol. By expressing the genes involved in the production of pleuromutilin in a different type of fungus, the ...
Biochemistry
May 4, 2016
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(Phys.org) -- Edward Yu took note of the facts – nearly 2 million deaths each year, 9 million infected each year, developments of multidrug-resistant, extensively drug-resistant and now totally drug-resistant strains ...
Biochemistry
Aug 22, 2012
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For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a ...
Evolution
Nov 18, 2020
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Combining the innovations of synthetic biology with biology and chemistry, a team of scientists at the University of Bristol have generated a brand-new platform that will allow the production of desperately needed brand-new ...
Biochemistry
Nov 28, 2017
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A Brock University research team has created a microscopic robot that has the potential to identify drug resistance to tuberculosis faster than conventional tests.
Biochemistry
Jul 24, 2018
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(PhysOrg.com) -- Colorado State University researchers have discovered an enzyme that is critical to the survival and replication of the bacterial pathogen that causes tuberculosis. The enzyme may become a key target for ...
Biochemistry
Nov 21, 2011
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A chemist based at the University of Copenhagen has just taken out a patent for a drug that can make previously multidrug-resistant bacteria once again responsive to antibiotics. Jørn Bolstad and his chemist colleagues hope ...
Biochemistry
Feb 17, 2014
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Active tuberculosis will kill about two of every three people affected if left untreated. Treated tuberculosis has a mortality rate of less than 5%.
The standard "short" course treatment for tuberculosis (TB), is isoniazid, rifampicin, pyrazinamide, and ethambutol for two months, then isoniazid and rifampicin alone for a further four months. The patient is considered cured at six months (although there is still a relapse rate of 2 to 3%). For latent tuberculosis, the standard treatment is six to nine months of isoniazid alone.
If the organism is known to be fully sensitive, then treatment is with isoniazid, rifampicin, and pyrazinamide for two months, followed by isoniazid and rifampicin for four months. Ethambutol need not be used.
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