Scaling up cell imaging
Scientists have learned a lot about human biology by looking at cells under a microscope, but they might not notice tiny differences between cells or even know what they're looking for. Researchers at the Broad Institute ...
Scientists have learned a lot about human biology by looking at cells under a microscope, but they might not notice tiny differences between cells or even know what they're looking for. Researchers at the Broad Institute ...
Cell & Microbiology
Aug 03, 2022
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26
Scientists at the University of Nottingham have made a major breakthrough in understanding how malaria parasites divide and transmit the disease, which could be a major step forwards in helping to prevent one of the biggest ...
Molecular & Computational biology
Jul 28, 2022
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73
Researchers have discovered a significant and previously unknown mechanism that many bacteria use to resist antibiotics.
Molecular & Computational biology
Jul 28, 2022
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207
Body temperature is a basic indicator of health. Intracellular temperature is also a basic indicator of cellular health; cancer cells are more metabolically active, and thus can have a slightly higher temperature than healthy ...
Bio & Medicine
Jul 28, 2022
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36
Differentiation of pluripotent stem cells (PSCs) is regulated through a methionine-mediated mechanism, which has now been pinpointed by Tokyo Tech researchers. They have revealed that zinc (Zn) plays a crucial role in PSC ...
Cell & Microbiology
Jul 19, 2022
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33
In a study recently published in Cell Reports Methods, co- authors Björn Önfelt, Niklas Sandström and Valentina Carannante, researchers at SciLifeLab and the Department of Microbiology, Tumor and Cell Biology at Karolinska ...
Cell & Microbiology
Jul 19, 2022
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17
Researchers from Skoltech, MSU, Sirius University of Science and Technology and Institute of Bioorganic Chemistry of RAS investigated the role of two bacterial genes that aids in maintaining the integrity of ribosomal RNA ...
Cell & Microbiology
Jul 18, 2022
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11
A new technique that can analyze how drug molecules bind to proteins in tissue samples could offer an improved route to drug discovery and development.
Biochemistry
Jul 14, 2022
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A new biomedical research tool that enables scientists to measure hundreds of functional proteins in a single cell could offer new insights into cell machinery. Led by Jun Wang, Associate Professor of Biomedical Engineering ...
Biotechnology
Jun 29, 2022
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32
Dystroglycans on epithelial cell surfaces interact with the extracellular matrix via long sugar chains (called matriglycans), and they are responsible for cell adhesion. Abnormalities in the formation of matriglycans can ...
Biochemistry
Jun 27, 2022
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6
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed.
In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.
The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.
Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, "expensive, difficult, and inefficient process" with low rate of new therapeutic discovery. Information on the human genome, its sequence and what it encodes has been hailed as a potential windfall for drug discovery, promising to virtually eliminate the bottleneck in therapeutic targets that has been one limiting factor on the rate of therapeutic discovery.[citation needed] However, data indicates that "new targets" as opposed to "established targets" are more prone to drug discovery project failure in general[citation needed] This data corroborates some thinking underlying a pharmaceutical industry trend beginning at the turn of the twenty-first century and continuing today which finds more risk aversion in target selection among multi-national pharmaceutical companies.[citation needed]
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