Researchers are using zombie-like cells that behave normally on the outside, but are filled with magnetic particles inside, to screen potential drugs from natural products.
Bio & Medicine
May 10, 2019
0
88
Precise measurements are critical to the discovery, development and usage of medications. Major financial and scientific decisions within pharmaceutical companies are informed by the outcomes of chemical and biological analyses. ...
Analytical Chemistry
May 02, 2019
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7
A new chemical synthesis strategy to harvest the rich information found in natural products—organic compounds isolated from natural sources—has led to the identification of novel, simpler derivatives with potential to ...
Materials Science
Apr 24, 2019
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37
Gene editing has been a much sought after and controversial technology. Last month, part of the World Health Organization called for an international registry to track all research into editing the human genome.
Biotechnology
Apr 03, 2019
0
160
A new study by UAlberta biologists shows the first evidence of apoptosis, or programmed cell death in algae. The outcomes have broad-reaching implications, from the development of targeted antibiotics to the production of ...
Cell & Microbiology
Mar 21, 2019
0
128
Old molecules and new complexes: researchers at Hollings Cancer Center at the Medical University of South Carolina (MUSC) have discovered cell membrane complexes called ceramidosomes that may be a new target for drugs to ...
Biochemistry
Feb 13, 2019
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39
Researchers have designed a machine learning algorithm for drug discovery which has been shown to be twice as efficient as the industry standard, which could accelerate the process of developing new treatments for disease.
Biochemistry
Feb 11, 2019
0
160
Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such "make-on-demand" compounds readily available ...
Biochemistry
Feb 06, 2019
0
59
Scientists have revealed the structure of a virus infecting bacteria that thrive in 160-degree hot springs in places like Yellowstone National Park in Wyoming.
Cell & Microbiology
Feb 04, 2019
0
130
Vampire bats could hold the key to new treatments for a range of serious medical problems, but researchers have hit a snag accessing the specimens needed to advance their work.
Biochemistry
Jan 15, 2019
0
20
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed.
In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.
The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.
Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, "expensive, difficult, and inefficient process" with low rate of new therapeutic discovery. Information on the human genome, its sequence and what it encodes has been hailed as a potential windfall for drug discovery, promising to virtually eliminate the bottleneck in therapeutic targets that has been one limiting factor on the rate of therapeutic discovery.[citation needed] However, data indicates that "new targets" as opposed to "established targets" are more prone to drug discovery project failure in general[citation needed] This data corroborates some thinking underlying a pharmaceutical industry trend beginning at the turn of the twenty-first century and continuing today which finds more risk aversion in target selection among multi-national pharmaceutical companies.[citation needed]
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