Related topics: protein · drug · molecules · compounds · new drugs

Breakthrough virus simulations tackle the flu

A team of researchers from the University of California San Diego and the University of Pittsburgh offers a new approach for developing treatments for influenza.

Essential oil components can be tested as drug candidates

A research team at the VIB-KU Leuven Center for Microbiology and the KU Leuven Department of Biology showed that, contrary to generally held belief, most components of essential oils could meet the criteria set for drug candidates. ...

Monitoring organs and cells in living fly larvae

Small changes in a cell's composition can radically transform its function and drive the development of diseases like diabetes, cancer or neuronal dysfunction. Scientists led by the European Molecular Biology Laboratory in ...

Microswimmers swim faster over slippery surfaces

Tiny self-propelling spheres, measuring only micrometers, move faster over a hydrophobic silicone surface than they do over hydrophilic glass. "Almost nobody had realized that the substrate matters," says Stefania Ketzetzi, ...

Melting reveals drug targets in a living organism

Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory ...

Using a chip to find better cancer fighting drugs

Kyoto University researchers have developed a new 'tumor-on-a-chip' device that can better mimic the environment inside the body, paving the way for improved screening of potential cancer fighting drugs.

Synthetic compound provides fast screening for potential drugs

A simple assay may benefit drug discovery for treating diabetes, Parkinson's, and Alzheimers disease, as well as studies of functional food and endocrine disruptor report researchers at Okayama University in the Journal of ...

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Drug discovery

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed.

In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.

The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.

Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, "expensive, difficult, and inefficient process" with low rate of new therapeutic discovery. Information on the human genome, its sequence and what it encodes has been hailed as a potential windfall for drug discovery, promising to virtually eliminate the bottleneck in therapeutic targets that has been one limiting factor on the rate of therapeutic discovery.[citation needed] However, data indicates that "new targets" as opposed to "established targets" are more prone to drug discovery project failure in general[citation needed] This data corroborates some thinking underlying a pharmaceutical industry trend beginning at the turn of the twenty-first century and continuing today which finds more risk aversion in target selection among multi-national pharmaceutical companies.[citation needed]

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