In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before being contained within the nucleus.
Molecular & Computational biology
Sep 22, 2023
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1
The intricate interplay of gene expression within living cells is akin to a well-orchestrated symphony, with each gene playing its part in perfect harmony to ensure cells function as they should. At the heart of this symphony ...
Cell & Microbiology
Sep 19, 2023
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135
A new study led by University of Maryland physicists sheds light on the cellular processes that regulate genes. Published in the journal Science Advances, the paper explains how the dynamics of a polymer called chromatin—the ...
Molecular & Computational biology
Aug 15, 2023
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11
Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the highly regulated enzymatic ...
Cell & Microbiology
Jul 10, 2023
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92
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and ...
Molecular & Computational biology
Jun 30, 2023
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50
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin have revealed how cells accelerate changes to their identity, ...
Cell & Microbiology
Jun 27, 2023
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58
Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children's Research Hospital are exploring how a type of transcription factor ...
Cell & Microbiology
May 24, 2023
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137
Have you ever wondered why some people might get sicker than others, even when they catch the same virus? It is not yet clear why this is. Viral factors (such as differences in the strain of a virus) play a role in this variability, ...
Cell & Microbiology
May 12, 2023
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78
New insight into proteins called "pioneer factors" helps to explain their unusual ability to open up the typically dense genetic material within our cells. This behavior makes the genetic material accessible for proteins ...
Cell & Microbiology
Apr 20, 2023
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20
If one imagines the genome as an instruction manual for the functioning of a cell, every page of this manual is covered with annotations, highlights, and bookmarks. The role of some of these marks remains mysterious—do ...
Cell & Microbiology
Feb 20, 2023
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