Mechanism for hMTH1's broad substrate specificity revealed

Human MutT homolog 1 (hMTH1) protein acts as the primary enzyme for breaking down (hydrolyzing) damaged (oxidized) deoxynucleoside triphosphates (dNTPs) the substrates of DNA synthesis. Recently, hMTH1 has drawn attention ...

Evolutionarily conserved enzyme play key role in DNA replication

Genome-wide studies of fission yeast (Schizosaccharomyces pombe) suggest that the evolutionary conserved enzyme Pfh1 helicase facilitates DNA synthesis by tracking along with the replication apparatus, promoting intact DNA ...

The protein that assesses distances

A protein of the ISWI family (Imitation Switch, or nucleosome remodelling motors) is endowed with a special property: despite having no organ of sense it is nonetheless able to assess the length of DNA strands. A study just ...

The next pandemic could be downloaded from the internet

Last October, scientists in California sequenced the DNA for the "type H" botulinum toxin. One gram of this toxin would be sufficient to kill half a billion people, making it the deadliest substance yet discovered – with ...

Microelectronics: Automating cancer detection

Microelectronic engineers in Singapore have developed and tested sensor technology that can detect and measure a chemical signature of bladder cancer. The light-based sensor could eventually be used for the early diagnosis ...

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