Even dying stars can still give birth to planets

Planets are usually not much older than the stars around which they revolve. Take the sun: It was born 4.6 billion years ago, and not long after that, Earth developed. But KU Leuven astronomers have discovered that a completely ...

Blackhole with warped accretion disc discovered

An international team of astrophysicists from South Africa, the UK, France and the US have found large variations in the brightness of light seen from around one of the closest black holes in our Galaxy, 9,600 light-years ...

New technique used to discover how galaxies grow

For decades, space and ground telescopes have provided us with spectacular images of galaxies. These building blocks of the universe usually contain several million to over a trillion stars and can range in size from a few ...

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DLG4

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.

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