The rare molecule weighing in on the birth of planets

Astronomers using one of the most advanced radio telescopes have discovered a rare molecule in the dust and gas disc around a young star—and it may provide an answer to one of the conundrums facing astronomers.

New coating process provides effective protection for brake discs

More than many other auto parts, brake discs are subject to repeated mechanical loads. As a result of this continual abrasion, they produce fine particulate matter, which pose a substantial environmental burden. Now, however, ...

Second baby planet found using pioneering technique

Monash astrophysicists using the ALMA telescope in Chile have a made a world-first discovery with the sighting of a second new 'baby' planet (two to three times heavier than Jupiter) inside a gas and dust gap.

Massive brown dwarf detected by astronomers

An international team of astronomers has found a new brown dwarf, one of the most massive objects of this type discovered to date. The newly detected brown dwarf, designated EPIC 212036875 b, turns out to be about 50 times ...

Oldest axial fossils discovered for the genus Australopithecus

Scientists have published an article describing the oldest axial fossils yet discovered for the genus Australopithecus. Dated 4.2 million years ago, these and other fossils recovered from the Assa Issie site in the Middle ...

Brown dwarfs are formed in the same way as sun-like stars

Astronomers have discovered a so-called proto-disc around the proto-brown dwarf Mayrit. With this discovery, they were able to confirm for the first time that this celestial body was formed in the same way as sun-like stars.

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DLG4

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.

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