How dinosaur research can help medicine

The intervertebral discs connect the vertebrae and give the spine its mobility. The disc consists of a cartilaginous fibrous ring and a gelatinous core as a buffer. It has always been assumed that only humans and other mammals ...

Strange gamma-ray heartbeat puzzles scientists

Scientists have detected a mysterious gamma-ray heartbeat coming from a cosmic gas cloud. The inconspicuous cloud in the constellation Aquila is beating with the rhythm of a neighboring precessing black hole, indicating a ...

Milky Way's warp caused by galactic collision, Gaia suggests

Astronomers have pondered for years why our galaxy, the Milky Way, is warped. Data from ESA's star-mapping satellite Gaia suggest the distortion might be caused by an ongoing collision with another, smaller, galaxy, which ...

ESA's next sun mission will be shadow-casting pair

After Solar Orbiter, ESA's next mission observing the sun will not be one spacecraft but two: the double satellites making up Proba-3 will fly in formation to cast an artificial solar eclipse, opening up the clearest view ...

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DLG4

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.

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