Cellular trash cans reveal the roles of proteins in disease

If we really want to know how our body's cells work—or don't work, in the case of disease—we might need to look beyond their genes and even beyond the proteins they are made of. We may need to start going through the ...

Mayo researchers find off/on switch for DNA repair protein

Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets ...

Biologists' new peptide could fight many cancers

MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.

DNA damage repair—molecular insights

The first line of defense against skin cancer is the ability to repair DNA damage caused by UV light. The XPA protein plays an important role in the repair of certain DNA damage, and mutations in this protein have been implicated ...

A hair-trigger for cells fighting infection

To fight infections cells in the immune system play a dangerous game with their own genes. Damaging genes allows B cells to make antibodies that are specifically equipped to target to specific causes of illness, but damaging ...

Fast-forward aging due to DNA damage

The heredity substance DNA is the blueprint of our life. Like an instruction manual it contains all the information needed for cells and the body to function properly. In the process, the DNA is always exposed to threats ...

A molecular plaster to repair DNA

All cells are confronted with DNA damage, for example by exposure of the skin to UV rays, chemical byproducts of nerve cells consuming sugar, or immune cells destroying bacteria. If these DNA lesions are not - or badly - ...

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