Snapshots of the smallest programmable nuclease TnpB published

A team led by Professor Virginijus Šikšnys from Vilnius University Life Sciences Center (VU LSC) determined the structure of TnpB using cryo-electron microscopy in collaboration with the group of Professor Guillermo Montoya ...

Ibogaine inspires new compounds to treat addiction, depression

Scientists have developed two new drug candidates for potentially treating addiction and depression, modeled on the pharmacology of a traditional African psychedelic plant medicine called ibogaine. At very low doses, these ...

How does an aging-associated enzyme access our genetic material?

New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn State researchers have ...

Humans vs. bacteria: Differences in ribosome decoding revealed

Scientists at St. Jude Children's Research Hospital revealed that human ribosomes decode messenger RNA (mRNA) 10 times slower than bacterial ribosomes, but do so more accurately. The study, published today in Nature, used ...

Calcium sensor helps us to see the stars

Using cryo-electron microscopy and mass spectrometry, researchers from PSI have deciphered the structure of an ion channel found in the eye while it interacts with the protein calmodulin—a structure that has eluded scientists ...

Basic science shows how a single mutation causes ataxia

Worldwide, only a handful of patients are known to suffer from episodic ataxia type 6, a neurological disease that causes transient loss of muscle control. The cause lies in a mutation that changes a single amino acid in ...

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