Mechanism of bacterial toxins in deadly attacks

Only one thousandth of a milligram of the bacterial botulinum toxin is necessary to kill a living organism. The toxin unfolds its lethal effect by preventing the release of neurotransmitters at the point where nerve cells ...

Discovery offers starting point for better gene-editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases. However, there is a last-mile problem—these tools need to be effectively ...

New 3D structure could lead to future drugs against cancer

A team of scientists has created a three-dimensional map showing how a small molecule with anticancer properties—called spliceostatin—can promote the killing of cancer cells. This fundamental discovery could ultimately ...

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