Structural studies offer 'how-to' guide for designing cancer drugs
To design drugs that stall the growth of aggressive cancers, it helps to know the structures of the proteins that are revving the cancers' engines.
To design drugs that stall the growth of aggressive cancers, it helps to know the structures of the proteins that are revving the cancers' engines.
Biochemistry
Dec 9, 2022
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82
While many materials melt when heated, researchers from Japan recently discovered a novel material in which melting can be induced by ultraviolet light instead of heat. Even more intriguing, this material exhibits changes ...
Materials Science
May 16, 2023
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244
Molecules that are induced by light to rotate bulky groups around central bonds could be developed into photo-activated bioactive systems, molecular switches, and more.
Analytical Chemistry
Feb 28, 2024
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76
Researchers in the lab of John Kuriyan, professor of biochemistry and dean of the School of Medicine Basic Sciences, have revealed a key element of how a molecular machine responsible for high-speed DNA replication works. ...
Molecular & Computational biology
Feb 9, 2024
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50
Computational chemist Mahmoud Moradi will develop enhanced, 3-D simulations of the molecular dynamics of coronavirus spike glycoproteins to gain better understanding of how the virus binds to human cells.
Biochemistry
Apr 15, 2020
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11
For people who identify as LGBT+, the workplace can be a difficult environment to manage. One in five lesbian, gay and bisexual employees say they have experienced verbal bullying. For those who are transgender and gender ...
Social Sciences
May 30, 2019
33
108
Ribosomes, the essential machinery used for protein synthesis is recycled after each one round of translation. An enzyme called ABCE1 is responsible for this process and turns out to be remarkably plastic as LMU biophysicists ...
Cell & Microbiology
Jul 18, 2019
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104
A team of researchers from Weill Cornell Medical School's Department of Physiology and Biophysics has developed a new computational technique to conduct molecular dynamics simulations of proteins at the specific concentration ...
Cell & Microbiology
Dec 7, 2021
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377
University of Groningen scientists have observed the characteristics of a single enzyme inside a nanopore. They learned that the enzyme can exist in four different folded states, or conformers, that play an active role in ...
Biochemistry
Apr 6, 2020
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27
Atomic oxygen is created when O2 molecules break apart, a process made easier in space because of the abundance of ultraviolet radiation. According to NASA, 96 percent of low-Earth orbit's atmosphere is atomic oxygen, a reality ...
Materials Science
Feb 16, 2021
1
46