A team of scientists led by the iHuman Institute of ShanghaiTech University has determined and analyzed the cryo-electron microscopy structures of human bitter taste receptor TAS2R46 complexed with G protein, in both strychnine-bound ...
Cell & Microbiology
Sep 15, 2022
1
22
Thyroid hormone (TH) plays a multifunctional role in metabolism and development in vertebrates. The synthesis and secretion of TH is determined by the hypothalamus-pituitary-thyroid (HPT) axis. The tripeptide thyrotropin-releasing ...
Cell & Microbiology
Apr 29, 2022
0
20
A team of researchers from Weill Cornell Medical School's Department of Physiology and Biophysics has developed a new computational technique to conduct molecular dynamics simulations of proteins at the specific concentration ...
Cell & Microbiology
Dec 7, 2021
0
377
Maria Kowalski-Jahn and Hannes Schihada, two postdocs in the Schulte laboratory, have used a novel technology of fluorescently labeling receptors with a minimally invasive technique and detecting structural rearrangements ...
Cell & Microbiology
Nov 11, 2021
0
7
A group of researchers led by scientists from the RIKEN Center for Emergent Matter Science and the University of Tokyo has created an unusual material—a soft crystal made of molecules known as a catenanes—that behaves ...
Condensed Matter
Oct 13, 2021
0
34
Researchers of the University of Oulu, Finland, have for the first time uncovered the molecular structure of a key protein, PARP2, when bound to damaged DNA. PARP2 is one of the key enzymes protecting and maintaining our ...
Biotechnology
Jun 9, 2021
0
4
Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St. Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins—that is, ...
Molecular & Computational biology
Dec 7, 2020
0
50
Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NS-ML) are rare human developmental disorders caused by mutations of the protein SHP2. Until recently, the mechanism of NS and NS-ML pathogenesis had been ...
Molecular & Computational biology
Oct 1, 2020
0
8
Mitochondria are the powerhouses of our cells, generating energy that supports life. A giant molecular proton pump, called complex I, is crucial: It sets in motion a chain of reactions, creating a proton gradient that powers ...
Cell & Microbiology
Sep 24, 2020
0
425
Human cells sense and communicate via cell surface receptors. Information about the environment is relayed to the inside of the cell through dynamic changes in their arrangement or conformation. To gain better understanding ...
Plants & Animals
Jun 23, 2020
0
3
