The natural defenses of ticks could help improve anti-inflammatory drugs
Research is using ticks to help unlock better ways to fight inflammation, which causes considerable suffering in people globally.
Research is using ticks to help unlock better ways to fight inflammation, which causes considerable suffering in people globally.
Biochemistry
Jul 18, 2023
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95
MIT Media Lab researchers have discovered that shortened versions of immunity-related protein receptors, long written off as incomplete and therefore nonfunctional, can bind with their natural counterparts on the cell membrane ...
Biotechnology
Oct 29, 2020
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33
Proteins found in tick saliva could be used to treat a potentially fatal form of heart disease, according to new Oxford University research.
Biochemistry
Jun 27, 2017
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(Phys.org) —Migrating cells, it seems, cover their tracks not for fear of being followed, but to keep moving forward. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have now shown ...
Cell & Microbiology
Sep 26, 2013
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0
Human immune cells are capable of coordinating their own movement more independently than previously thought. InFLAMES researcher Jonna Alanko has discovered that immune cells do not just passively follow the chemical cues ...
Cell & Microbiology
Sep 6, 2023
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0
Chemokine receptors regulate the migration of immune cells and are involved in inflammation, tumor construction and pathogen infection. Chemokines are divided into four subfamilies according to the number and distribution ...
Biochemistry
Jul 7, 2022
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6
A new study led by Prof Shoumo Bhattacharya has decoded the structure of unique proteins found in tick saliva and created new ones not found in nature, paving the way for a new generation of "Swiss-army knife' anti-inflammatory ...
Plants & Animals
Jul 18, 2019
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19
A discovery about the way in which bugs spread throughout the body could help to develop stem cell treatments.
Cell & Microbiology
Jan 17, 2013
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Three specific biomarkers provide an accurate indication of the severity of Chikungunya fever (CHIKF), which is emerging as a threat in South-East Asia, the Pacific and Europe, according to research conducted in Singapore.
Cell & Microbiology
Mar 4, 2009
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0
Chemokines (Greek -kinos, movement) are a family of small cytokines, or proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. However, these proteins have historically been known under several other names including the SIS family of cytokines, SIG family of cytokines, SCY family of cytokines, Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria, but none have been described for other invertebrates. These proteins exert their biological effects by interacting with G protein-linked transmembrane receptors called chemokine receptors, that are selectively found on the surfaces of their target cells.
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