(PhysOrg.com) -- The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. ...
Analytical Chemistry
Nov 26, 2009
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A molecular biologist at the University of Massachusetts Amherst who has for decades studied the nightmarish group of fatal diseases caused by prions—chronic wasting disease in deer, mad cow in cattle and its human analog—credits ...
Molecular & Computational biology
May 6, 2020
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162
Influenza viruses mutate rapidly, which is why flu vaccines have to be redesigned every year. A new study from MIT sheds light on just how these viruses evolve so quickly, and offers a potential way to slow them down.
Biochemistry
Sep 26, 2017
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284
(Phys.org) —A protein that acts as a chaperone and escorts pathogenic bacteria through the acid bath of the human stomach actually needs to lose its shape in order to work.
Cell & Microbiology
Mar 5, 2013
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Proteins are the molecular building blocks and machinery of cells and involved in practically all biological processes. To fulfil their tasks, they need to be folded into a complicated three-dimensional structure. Scientists ...
Cell & Microbiology
Mar 8, 2012
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1
(Phys.org)—Heidelberg molecular biologists have gained new insights into the function of so-called molecular chaperones in protein synthesis. The team headed by Dr. Günter Kramer and Prof. Dr. Bernd Bukau of the DKFZ-ZMBH ...
Cell & Microbiology
Aug 25, 2012
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Amyloid fibers are protein aggregates associated with numerous neurodegenerative diseases, including Parkinson's disease, for which there are no effective treatments.
Biochemistry
Jun 19, 2012
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Proteins can only perform their complex functions in the cell when they assume a specific three-dimensional structure for each respective task. Because misfolded proteins are often toxic, they are immediately refolded or ...
Cell & Microbiology
Jun 21, 2013
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The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Biotechnology
Sep 7, 2011
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0
A special group of proteins, the so-called chaperons, helps other proteins to obtain their correct conformation. Until now scientists supposed that hydrolyzing ATP provides the energy for the large conformational changes ...
Cell & Microbiology
Jan 13, 2012
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