Commonly used chemical fixation causes aggregation artifact
Researchers at Kanazawa University report in Communications Biology that using common chemicals for fixing living cell samples for microscopy studies causes membrane proteins to aggregate.
Researchers at Kanazawa University report in Communications Biology that using common chemicals for fixing living cell samples for microscopy studies causes membrane proteins to aggregate.
Biochemistry
Aug 10, 2022
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24
Investigators have discovered that two cytoskeletal proteins which were previously thought to function independently actually interact and form cytoskeletal networks within the cell surface, according to findings published ...
Cell & Microbiology
Apr 8, 2022
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70
A mutated protein causes the genetic disease cystic fibrosis. Now, researchers have solved the structure of the protein and how certain drugs bind to it, unveiling their mode of action.
Cell & Microbiology
Jan 7, 2022
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590
Scientists at ETH Zurich have developed a new method to determine how proteins are organized on the surface of cells. Insights gained with the technology could lead to the development of novel drugs to fight cancer.
Cell & Microbiology
Dec 2, 2021
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112
Centrioles are cylindrical structures involved in the generation of microtubules—fibers inside of cells that form a network to provide structure and shape to cells and to mediate transport processes. In addition, centriole ...
Molecular & Computational biology
Nov 1, 2021
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54
For decades, scientists suspected that bacteria known as Geobacter could clean up radioactive uranium waste, but it wasn't clear how the microbes did it.
Cell & Microbiology
Aug 12, 2021
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388
Scientists at the Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have revealed molecular mechanisms involved in eliminating unwanted cells in the body. A nuclear protein fragment released ...
Cell & Microbiology
Mar 26, 2021
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955
Plants perceive pathogens and activate immunity using two very different types of receptors. Receptors at the cell surface detect pathogen-derived molecules that accumulate outside plant cells, activating pattern-triggered ...
Plants & Animals
Mar 11, 2021
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120
An LMU research team led by Nicolai Siegel has uncovered a mechanism that enables the parasite that causes sleeping sickness in humans to escape the attention of the immune system. The finding may also be relevant to other ...
Cell & Microbiology
Jan 12, 2021
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17
Researchers from Duke-NUS Medical School in Singapore and Columbia University in the U.S. have solved how Wnt proteins, which play a fundamental role in cell proliferation and differentiation, hitch a ride to travel from ...
Cell & Microbiology
Jan 12, 2021
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32